Grado:

Doctor en Ciencias, Universidad de Chile, 1969.

Tema de investigación o interés:

•Transporte de iones mediados por canales de iones: Relaciones entre estructura y función obtenida mediante Biología Molecular, Fluorescencia y Electrofisiología.

•Transporte de iones mediado por canales de iones en membranas biológicas y artificiales. Aspectos moleculares de la activación y conducción en canales de iones. Modulación metabólica de canales de iones. Canales de iones y hormonas.

Research Interest:

Ion transport mediated by ion channels in biological and artificial membranes. Molecular aspects of ion channel conductance and gating. Metabolic modulation of ion channels. Ion channels and hormones

Distinciones y premiaciones:

•President, Society of Latin American Biophysicists (SOBLA) (elected) – (1986-1988).

•Elizabeth R. Cole Award. Biophysical Society, USA for “A significant advance in biophysics which is accepted And use by other in the field”. (1989).

•Distinguished Visiting Professor, Baylor College of Medicine, Houston, TX USA. (1989).

•John Simon Guggenheim Memorial Foundation Fellowship. (1990).

•Best Teacher Award. Department of Biology, Facultad of Sciences, University of Chile. (1991).

•Third World Academy of Sciences Award in Biology. ( 1991).

•Dies Academicus, Main Speaker. Univrsity of Ulm, Germany. (1992).

•Member of the Latin American Academy of Sciences. (1993).

•Presidential Cathedra Award, Santiago, Chile. (1996).

•Medalla Rectorial, Universidad de Chile. (1996).

•Fellow of the Third World Academy of Sciences. (1997).

•Vice President, International Union of Physiological Sciences (IUPS) (elected). (1997).

•Corresponding Member of the Brazilian Academy of Sciences. (1998).

•Foreign Associate, National Academy of Sciences of the United States of America. (1999).

•Presidential Cathedra Award, Santiago Chile (Competitive renewal). (1999).

•Corresponding Member of the Chilean Academy of Sciences. (2002).

•National Prize in Natural Sciences bestowed by the Chilean Government. (2002).

•Medalla Rectorial University of Chile. (2002).

•Member, Molecular, Biophysics of Synapsis, Channels and Transporters Study Section

National Institutes of Health, USA. (2003-2006).

•Robert F. Kennedy Professor of Latin American Studies, Harvard University, Boston, MA. (2003).

•Council Member, Academia of Sciences of Latin America (elected). (2006).

•Visiting Scholar, The University of Chicago, Illinois, USA. (2007).

•Mexican Award in Science and Technology, bestowed by the Mexican Government to distinguish Scientists of Latin America (except Mexico), Spain and Portugal (2008).

Proyectos:

•“Bases moleculares de la sensibilidad térmica en mamíferos”

FONDECYT

Investigador responsable: Prof. Ramón Latorre

Co-investigador: Prof. Osvaldo Álvarez A.

Duración: 2007 – 2011

Publicaciones:

•Latorre, R. Muñoz, F. González, C. and Cosmelli,D. 2003. Structure and function of potassium channels in plants: some inferences about the molecular origin of inward rectification in KAT1 channels. Mol. Memb. Biol. 20:19-25

•Hebeisen, S., Heidtmann, H., Cosmelli, D., Gonzalez, C., Poser, B., Latorre, R., Álvarez, O. and Fahlke, C. 2003. Anion Permeation in Human Cic-4 Channels. Biophys. J. 84:2306-2318.

•Latorre, R., Olcesse, R., Basso, C., Gonzalez, C., Muñoz, F., Cosmelli, D. and Alvarez, O. 2003. Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1. J. Gen. Physiol. 122:459-469.

•Latorre, R. 2004. Vagabundeos por el jardín de la mente. Segunda Jornada de Investigación. Universidad de Talca.

•Latorre, R. and F. Morera. 2004. Voltage-Dependent K+ Channels. In: Encyclopedia of Biological Chemistry. Lennarz, W.J. and Lane, M.D. editors. Elsevier. Vol. 4: 399-404

•Fernádez-Fernández, J. M., Tomás, M., Vázquez, E., Orio, P., Latorre, R., Sentí, M., Marrugat J. and Valverde, M. A.. 2004. Gain-of-function mutation in the calcium-activated potassium channels  subunit associated with low prevalence of diastolic hypertension. J. Clinical Invest. 113:1032-1039

•Brauchi, S. Orio, P., and Latorre, R. 2004. Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc. Natl. Acad. Sci. (USA) 101:15494-15499

•Alvarez, O. Rosenmann, E. Bezanilla, F., González, C., and Latorre, R. 2005. Helical nature of the voltage sensor. In: Pumps, Transporters and Ion Channels. Studies on Their Structure, Function and Cell Biology. Sepúlveda, F., Bezanilla, F. Eds. Plenum Press, NY. Pp. 93-101

•González C., Morera, F., Rosenmann, E., Alvarez, O., and Latorre, R. 2005. S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels. Proc. Natl. Acad. Sci. (USA) 102:5020-5025

•Orio, P., and Latorre, R. 2005. Differential effects of 1- and 2 –subunits on the BK channel activity. J. Gen. Physiol. 125:395-411

•Latorre, R. 2005. De máquinas moleculares y sueños. Anales de la Academia Chilena de Ciencias. 7:107-118

•Latorre, R. and Brauchi, S. 2006. Large conductance Ca2+-activated K+ (BK) channels: activation by Ca2+ and Voltage. Biol. Res. 39:385-401 (3)

•Morera, F., Vargas, G., and Latorre, R. 2007. Ion-Channel Reconstitution. In: Methods in Membrane Lipids. Dopico, A. Ed. Humana Press Inc., Totowa, NJ. Chapter 38, pp. 571-585. Part of the series: Methods in Molecular Biology, vol. 400.

•Brauchi, S., Orta, G., Salazar, M., Rosenmann, E., and Latorre, R. 2006.

A hot-sensing cold-receptor: C-terminal domain determines thermosensation in TRP channels. J. Neurosci. 26:4835-4840. (19)

•Latorre, R., and Moreno, M.E. 2006. Ciencia: unidad en la variedad. Revista Atenea 493:23-34

•Latorre, R., Vargas, G., Orta, G., and Brauchi, S. 2007. Voltage and temperature gating in thermoTRP channels. In: TRP Ion Channels Function in Sensory Transduction and Cellular Signaling Cascades. Liedtke, W. and Heller, S. Eds. CRC Taylor and Francis, London. Chapter 21, pp 287-302

•Brauchi S., Orta G., Mascayano C., Salazar M., Raddatz N., Urbina H.,

Rossenman E., Gonzalez-Nilo F., Latorre R. 2007. Dissection of the components for PIP2 activation and thermosensation in trp channels. Proc. Natl. Acad. Sci. (USA) 104:10246-10251.(9)

•Torres Y., Carvacho, I., Morera, F., and Latorre, R. 2007. A marriage of convenience: 1 subunits of voltage-dependent channels. J. Biol. Chem. 282:24495-24489

•Morera, F., Vargas, G., and Latorre, R. 2007. Ion-Channel Reconstitution. In: Methods in Membrane Lipids. Dopico, A. Ed. Humana Press Inc., Totowa, NJ. Chapter 38, pp. 571-585. Part of the series: Methods in Molecular Biology, vol. 400.

•Latorre, R., Brauchi, S., Orta, G., Zaelzer, C., Vargas, G. 2007. ThermoTRP Channels as Modular Proteins with Allosteric Gating. Cell Calcium 42:427-438 (1)

•Ingrid Carvacho, I, Gonzalez, W., Torres, Y., Brauchi, S., Alvarez, O., Gonzalez-Nilo, F.D., and Latorre, R. 2008. Intrinsic Electrostatic Potential in the BK Channel Pore: Role in Determining Single Channel Conductance and Block. Journal of General Physiology. 31:147-162

Contactar Academico