Grado:

Ph.D. en Bioquímica, University of Iowa, USA, 1973.

Tema de investigación o interés:

Biología

Biotecnología

Estudiamos los mecanismos sensoriales y de adaptación de algunos microorganismos, incluyendo extremófilos (acidófilos y termófilos), a los cambios estresantes de su entorno, como la falta de nutrientes o la presencia de contaminantes ambientales. Mediante el análisis de los cambios globales de la expresión de los genomas y proteomas de estas bacterias ante estas condiciones, la genética reversa y estudios funcionales, se espera poder desarrollar bacterias mejoradas para obtener productos de utilidad mediante biodegradación y para la biorremediación o control de contaminantes ambientales que afectan la salud humana, como metales pesados y compuestos organoclorados.

Proyectos:

•“Estudios del Quorum Sensing de tipo AI-1 mediado por el par génico afeR/afeI en la bacteria extremófila acidófila Acidithiobacillus ferrooxidans”

FONDECYT

Investigador responsable: Prof. Nicolás Guiliani

Co-investigador: Prof. Carlos Jerez G.

Duración: 2004 - 2008

•"Estudio de los determinantes de resistencia al cobre en bacterias y arqueas ambientales de uso en biominería y biorremediación"

FONDECYT

Investigador responsable: Prof. Carlos Jerez G.

Co-investigador: Prof. Francisco Chavéz

Duración: 2007 - 2010

•"Instituto Milenio en Dinámica Celular y Biotecnología"

Mideplan

Investigador clave: Prof. Carlos Jerez G.

Duración: 2006 - 2011

•"Biochemistry and proteomics of extremophilic microorganisms for the improvement of bioleaching of metals and metal sulfides"

DAAD/CONICYT

Investigador responsable de Chile: Prof. Carlos Jerez G.

Duración: 2007 - 2009

Publicaciones:

•M. Vera, N. Guiliani, C.A. Jerez

“Proteomic and genomic analysis of the phosphate starvation response of Acidithiobacillus ferrooxidans”

Hidrometallurgy 71, 125-132 (2003)

•Chávez, F., Lünsdorf, H. and Jerez, C.A.

Growth of polychlorinated biphenyl (PCB)-degrading bacteria in the presence of biphenyl and chlorobiphenyls generates oxidative stress and massive accumulation of inorganic polyphosphate.

Appl. Environ. Microbiol. 70:3064-3072 (2004)

•Ramírez., P., Guiliani, N., Valenzuela, L., Beard, S., and Jerez, C.A.

Differential protein expression during growth of Acidithiobacillus ferrooxidans on ferrous iron, sulfur compounds or metal sulfides.

Appl. Environ. Microbiol. 70: 4491-4498.(2004)

•Alvarez, S. and Jerez, C.A.

Copper ions stimulate polyphosphate degradation and phosphate efflux in Acidithiobacillus ferrooxidans. Appl. Environ. Microbiol. 70: 5177-5182.(2004)

•Acosta M., Beard S., Ponce J., Vera M., Mobarec J. C., Jerez C. A.

"Identification of putative sulfurtransferase genes in the extremophilic Acidithiobacillus ferrooxidans ATCC 23270 genome: structural and functional characterization of the proteins"

OMICS 9: 13 - 29 (2005)

•C. Farah, A. Banderas, C. Jerez, N. Guiliani

“Searching for physiological functions regulated by the quorum sensing autoinducer AI-1 promoted by afel/afeR genes in Acidithiobacillus ferroxidans”

In 15 th Internacional Biohydrometallurgy Symposium, Athens, Greece. Pp 151-159 (2003)

Appl. Environ. Microbiol 70: 3064 - 3072 (2004)

•Ramírez P., Guiliani N., Valenzuela, L., Jerez C. A

“Differential protein expression during growth of Acidithiobacillus ferrooxidans in ferrous iron, sulfur compounds and metal sulfides”

Appl. Environ. Microbiol 70: 4491 - 4498 (2004)

•Farah, C., Vera, M., Morin, D., Haras, D., Jerez, C.A. and Guiliani, N.

“Evidence of a functional quorum sensing type AI-1 system in the extremophilic bacterium Acidithiobacillus ferrooxidans”.

Appl. Environ. Microbiol. 71: 7033-7040 (2005)

•Chávez, F., Lünsdorf, H. and Jerez, C.A.

Growth of polychlorinated biphenyl (PCB)-degrading bacteria in the presence of biphenyl and chlorobiphenyls generates oxidative stress and massive accumulation of inorganic polyphosphate.

Appl. Environ. Microbiol. 70:3064-3072 (2004)

•Ramírez., P., Guiliani, N., Valenzuela, L., Beard, S., and Jerez, C.A.

Differential protein expression during growth of Acidithiobacillus ferrooxidans on ferrous iron, sulfur compounds or metal sulfides.

Appl. Environ. Microbiol. 70: 4491-4498.(2004)

•Alvarez, S. and Jerez, C.A.

Copper ions stimulate polyphosphate degradation and phosphate efflux in Acidithiobacillus ferrooxidans. Appl. Environ. Microbiol. 70: 5177-5182.(2004)

•Acosta M., Beard S., Ponce J., Vera M., Mobarec J. C., Jerez C. A.

"Identification of putative sulfurtransferase genes in the extremophilic Acidithiobacillus ferrooxidans ATCC 23270 genome: structural and functional characterization of the proteins"

OMICS 9: 13 - 29 (2005)

•C. Farah, A. Banderas, C. Jerez, N. Guiliani

“Searching for physiological functions regulated by the quorum sensing autoinducer AI-1 promoted by afel/afeR genes in Acidithiobacillus ferroxidans”

In 15 th Internacional Biohydrometallurgy Symposium, Athens, Greece. Pp 151-159 (2003)

Appl. Environ. Microbiol 70: 3064 - 3072 (2004)

•Ramírez P., Guiliani N., Valenzuela, L., Jerez C. A

“Differential protein expression during growth of Acidithiobacillus ferrooxidans in ferrous iron, sulfur compounds and metal sulfides”

Appl. Environ. Microbiol 70: 4491 - 4498 (2004)

•Farah, C., Vera, M., Morin, D., Haras, D., Jerez, C.A. and Guiliani, N.

“Evidence of a functional quorum sensing type AI-1 system in the extremophilic bacterium Acidithiobacillus ferrooxidans”.

Appl. Environ. Microbiol. 71: 7033-7040 (2005)

Publicaciones en Libros y similares

•Farah, C., Banderas, A., Jerez, C. A. and Guiliani, N. Searching for physiological functions regulated by the quorum sensing autoinducer AI-1 promoted by afeI/afeR genes in Acidithiobacillus ferrooxidans. In Biohydrometallurgy, a Sustainable Technology in Evolution. Symposium Proccedings, 15th International Biohydrometallurgy Symposium IBS 2003, Tsezos, M., Hatzikioseyian, A., Remoundaki, E., eds., Athens, Greece, pp. 1361-1368. (2004)

•Ramírez, P., Valenzuela, L., Acosta, M., Guiliani, N and Jerez, C.A. Expression proteomics of Acidithiobacillus ferrooxidans grown in different metal sulfides: analysis of rhodanese-like proteins. In Biohydrometallurgy, a Sustainable Technology in Evolution. Symposium Proccedings, 15th International Biohydrometallurgy Symposium IBS 2003,. Tsezos, M., Hatzikioseyian, A., Remoundaki, E., eds., Athens, Greece, pp. 1287-1296. (2004)

•Valenzuela S, Banderas A, Jerez CA, Guiliani N. Cell-Cell communication in bacteria. A promising new approach to improve bioleaching efficiency? In Microbial Processing of Metal Sulfides (E. Donati and W. Sand, Eds.), pp. 253-264. Springer, Netherland. (2007

•Jerez, C.A. Proteomics and metaproteomics applied to biomining microorganisms. In Microbial Processing of Metal Sulfides (E. Donati and W. Sand, Eds.), pp. 241-251. Springer.(2007)

Valenzuela, L., Chi, A., Beard, S., Shabanowitz, J., Hunt, D.F., and Jerez, C.A. Differential expression proteomics for the study of sulfur metabolism in the chemolithoautotrophic Acidithiobacillus ferrooxidans. In Microbial Sulfur Metabolism (C. Friedrich and C. Dahl., Eds.), pp. 77-86. Springer (2007

•Jerez, C.A. Biomining in the post-genomic age: advances and perspectives. Adv. Mat. Res. 20-21: 389-400 (2007)

•Jerez, C.A. Metal extraction and biomining, in The Encyclopedia of Microbiology, 3rd Edition, edited by Moselio Schaechter, Elsevier. In press.

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